Lindholm C, Bjellerup M, Ole Christensen, Zederfeldt B. Quality of life in chronic leg ulcer patients. Acta Derm Venereol (Stockh). 1993; 73:440-443
Stadelmann WK, Digenis AG, Tobin GR. Physiology and healing dynamics of chronic cutaneous wounds. Am J Surg. 1998; 176:(2)26S-38S
Schultz GS, Sibbald RG, Falanga V. Wound bed preparation: a systematic approach to wound management. Wound Repair Regen. 2003; 11:(S1)S1-S28
Position document: wound bed preparation in practice.: MEP Ltd; 2004
Van Der Plas MJA, Jukema GN, Wai SW Maggot excretions/secretions are differentially effective against biofilms of Staphylococcus aureus and Pseudomonas aeruginosa. J Antimicrobial Chemotherapy. 2008; 61:(1)117-122
Brown A, Blount DG, Horobin A Blow fly Lucilia sericata nuclease digests DNA associated with wound slough/eschar and with Pseudomonas aeruginosa biofilm. Med Veterinary Entomol. 2012; 26:(4)432-439
Pritchard DI, Brown AP. Degradation of MSCRAMM target macromolecules in VLU slough by Lucilia sericata chymotrypsin 1 (ISP) persists in the presence of tissue gelatinase activity. Int Wound J. 2015; 12:(4)414-421
Chambers L, Brown AP, Hall M Degradation of extracellular matrix components by defined proteinases from the greenbottle larva Lucilia sericata used for the clinical debridement of non-healing wounds. Br J Dermatol. 2003; 148:(1)14-23
Van Der Plas MJA, Jukema GN, Wai SW Maggot secretions suppress proinflammatory responses of human monocytes through elevation of cyclic AMP. Diabetologia. 2009; 52:(9)1962-1970
Van Der Plas MJA, Van Dissel JT, Nibbering PH Maggot secretions skew monocytemacrophage differentiation away from a pro-inflammatory to a proangiogenic type. PloS ONE. 2009; 4:(11)
Nygaard MKE, Andersen A, Kristensen H The insect defensin lucifensin from Lucilia sericata. J Biomolecular NMR. 2012; 52:(3)277-282
Dumville JC, Bland M, Cullum N Larval therapy for leg ulcers (VenUS II): randomised controlled trial. BMJ. 2009; 338
Soares MO, Iglesias CP, Bland JM Cost effectiveness analysis of larval therapy for leg ulcers. BMJ. 2009; 338
Mudge E, Price P, Neal W, Harding KG A randomized controlled trial of larval therapy for the debridement of leg ulcers: results of a multicenter, randomized, controlled, open, observer blind, parallel group study. Wound Repair Regen. 2014; 22:(1)43-51
Hall-Stoodley L, Bjarnsholt T, Costerton JW Towards diagnostic guidelines for biofilm-associated infections. FEMS Immunol Med Microbiol. 2012; 65:(2)127-145
Hill KE. Molecular analysis of the microflora in chronic venous leg ulceration. J Med Microbiol. 2003; 52:(4)365-369
Grey JE. Venous and arterial leg ulcers. BMJ. 2006; 332:(7537)
Humphreys ML, Gohel MS, Poskitt KR Management of mixed arterial and venous leg ulcers. Br J Surgery. 2007; 94:(9)1104-1107
Howell-Jones RS, Wilson MJ, Hill KE A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. J Antimicrobial Chemother. 2005; 55:(2)143-149
Andersen S, Joergensen B, Karlsmark T A novel approach to the antimicrobial activity of maggot debridement therapy. J Antimicrobial Chemother. 2010; 65:(8)1646-1654
Margolin L, Gialanella P. Assessment of the antimicrobial properties of maggots. Int Wound J. 2010; 7:(3)202-204
Bjarnsholt T, Høiby N, Givskov M Why chronic wounds will not heal: a novel hypothesis. Wound Repair Regen. 2008; 16:(1)2-10
Parnés A, Lagan KM. Larval therapy in wound management: a review. Int J Clin Practice. 2007; 61:(3)488-493
Cazander G, Nigam Y, Jung W Multiple actions of Lucilia sericata larvae in hard-to-heal wounds. Bioessays. 2013; 35:(12)1083-1092
Harris LG, Mack D, Nigam Y Lucilia sericata chymotrypsin disrupts protein adhesin-mediated staphylococcal biofilm formation. Applied Environmental Microbiol. 2013; 79:(4)1393-1395
Madsen SM, Danielsen L, Rosdahl VT, Westh H. Bacterial colonization and healing of venous leg ulcers. Apmis. 1996; 104:(7–8)895-99
Pritchard DI, Nigam Y. Maximising the secondary beneficial effects of larval debridement therapy. J Wound Care. 2013; 22:(11)610-11
Telford G, Brown AP, Seabra R Degradation of eschar from venous leg ulcers using a recombinant chymotrypsin from Lucilia sericata. Br J Dermatol. 2010; 163:(3)523-531
Burnand KG, Whimster I, Naidoo A, Browse NL. Pericapillary fibrin in the ulcer-bearing skin of the leg: the cause of lipodermatosclerosis and venous ulceration. Br Med J (Clin Res Ed). 1982; 285:(6348)1071-1072
Schultz GS, Wysocki A. Interactions between extracellular matrix and growth factors in wound healing. Wound Repair Regen. 2009; 17:(2)153-162
Telford G, Brown AP, Kind A Maggot chymotrypsin I from Lucilia sericata is resistant to endogenous wound protease inhibitors. Br J Dermatol. 2011; 164:(1)192-196
Bode W, FernandezCatalan C Insights into MMP-TIMP Interactions. Ann New York Acad Sci. 1999; 878:(1)73-91
Trengove NJ, Stacey MC, Macauley S Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Repair Regen. 1999; 7:(6)442-452
Serra R, Buffone G, Daniela F Chronic venous leg ulcers are associated with high levels of metalloproteinases-9 and neutrophil gelatinase-associated lipocalin. Wound Repair Regen. 2013; 21:(3)395-401
Rayment EA, Upton Z, Shooter GK Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer. Br J Dermatol. 2008; 158:(5)951-961
Schultz GS, Ladwig G, Wysocki A. Extracellular matrix: review of its roles in acute and chronic wounds.: World Wide Wounds; 2005
Clark R, Singer AJ. Cutaneous wound healing. New Engl J Med. 1999; 341:(10)738-746
Agren MS, Eaglstein WH, Ferguson MW Causes and effects of the chronic inflammation in venous leg ulcers. Acta dermato-venereologica Supplementum. 1999; 210:3-17
Greenhalgh T. How to read a paper: the basics of evidence-based medicine, 5th ed. : Wiley Blackwell; 2014
Tandara AA, Mustoe TA. Oxygen in wound healing–more than a nutrient. World J Surgery. 2004; 28:(3)294-300
Jonsson K, Hopf HW, Hunt TK Tissue oxygenation, anemia, and perfusion in relation to wound healing in surgical patients. Ann Surgery. 1991; 214:(5)
Igari K, Inoue Y, Jibiki M Maggot debridement therapy for peripheral arterial disease. Ann Vascular Dis. 2013; 6:(2)145-149
Maeda TM, Ichimura KI, Kimura CK, Takahashi KT. Increase in skin perfusion pressure after maggot debridement therapy for critical limb ischaemia. Clin Experimental Dermatol. 2014; 39:(8)911-914
