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Damage or stress causes cell necrosis. A necrotic cell loses membrane integrity and releases its intracellular contents including damage associated molecular patterns (DAMPs). These mediators may...
‘Today, debridement refers to deeply removing adherent, dead or contaminated tissue from a wound and must be clearly separated from the act of cleansing, defined as the removal of dirt (loose...
Biofilms are communities of microbes that are either associated with biotic or abiotic surfaces (not necessarily solid) or are attached to themselves. They are encased in a matrix of extracellular...
A retrospective chart review of patients with DFUs who attended the FTA clinic at a large, inner-city, tertiary care, academic hospital between January 2008 and January 2013 was conducted. Patients...
The aim of the study was to assess the potential of a micro capillary dressing to increase oxygenation, improve perfusion and reduction of oedema (tissue water index) in patients with therapy...
Early publications providing evidence for the presence of biofilm in chronic wounds have provided guidance for clinicians and researchers alike.10,11,39 These studies identified that biofilms were...
This systematic review was conducted to examine all types of quantitative research that explored the concepts of pH, exudate composition and/or temperature measurements in relation to wound healing in...
There is more published evidence on the effectiveness of debridement in diabetic foot ulcers (DFUs) than for venous leg ulcers (VLUs) and pressure ulcers (PUs).8 After debridement, systemic...
Slough is comprised of the components of phagocytosis and occurs as a consequence of the inflammatory phase of wound healing. In acute wounds, neutrophils remove any dead and devitalised tissue that...
A systematic review of the literature was conducted using PubMed, MEDLINE, and Google Scholar. Search terms used include: ‘diabetes’, ‘wounds’, ‘wound healing’, ‘diabetic wounds’, ‘immune...
The three risk factors for amputation illustrated as three intersecting rings of dominance (adapted from Armstrong and Mills)1.
DFUs that do not heal with standard care alone can be successfully treated with skin substitutes. However, these skin substitutes can be expensive, and once their use is initiated, treatment may still...
Patients with slow-healing, static, or deteriorating DFUs were selected by clinicians to take part in an evaluation of AQAg+. The clinicians were experienced in podiatry, and had previous experience...
A 35-year-old male who was diagnosed with type 2 diabetes 5 years ago presented at the Southern Arizona Limb Salvage Alliance (SALSA), following an accident where a nail pierced his left foot. The...
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