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Subunit structure of polyhexamethylene biguanide (PHMB). Schematic structure of mono-protonated PHMB with chloride as counter-ion (a) and monomers: hexamethylenediamine (b) and sodium dicyanamide (c).
Although there were a few VLUs in groups 1 and 2 and one PU in group 1, the differences in utility between unhealed and healed states are similar for these wounds compared to DFUs.17 (The difference...
This study showed concurrent validity with reference to native PAGE analysis for identifying and quantifying biofilm components through in vitro, in vivo and clinical investigations, as well as...
The 96-well plate biofilm method described here may provide an efficient and cost-effective high-throughput tool for studying biofilm formation, quantifying biofilm biomasses, testing antimicrobials...
We have developed a novel in vitro wound biofilm model that mimics the non-surface attached spatial distribution of mature biofilms found in wounds. For this purpose, bacteria known to build biofilms...
Existing technologies directed to the treatment of biofilms are intended to either penetrate the EPS that encapsulates the bacteria in a biofilm, or use dispersing agents, which typically target a...
A microbial biofilm is an organised community of bacteria, enveloped within a self-produced matrix, that can attach, for example, to a wound surface (Fig 1).19 The formation of a differentiated,...
Biofilms are now a major area of research for both clinicians and scientists. This research has increased significantly in the past decade due to advancements in emerging technologies and techniques...
Early publications providing evidence for the presence of biofilm in chronic wounds have provided guidance for clinicians and researchers alike.10,11,39 These studies identified that biofilms were...
There is more published evidence on the effectiveness of debridement in diabetic foot ulcers (DFUs) than for venous leg ulcers (VLUs) and pressure ulcers (PUs).8 After debridement, systemic...
Patients with slow-healing, static, or deteriorating DFUs were selected by clinicians to take part in an evaluation of AQAg+. The clinicians were experienced in podiatry, and had previous experience...
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