Ramundo JM. Wound Debridement, 5 edn. In: Bryant RA, Nix DP (eds). : Elsevier; 2016

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Graninger M, Grassberger M, Galehr E Comments, opinions, and brief case reports: biosurgical debridement facilitates healing of chronic skin ulcers. Arch Intern Med. 2002; 162:(16)1906-1907

Telgenhoff D, Shroot B. Cellular senescence mechanisms in chronic wound healing. Cell Death Differ. 2005; 12:(7)695-8

Sussman C, Bates-Jensen B Skin and Soft Tissue Anatomy and Wound Healing Physiology, 4 edn. In: Sussman C, Bates-Jensen B. : Wolters Kluwer Health/Lippincott Williams & Wilkins; 2012

Hamm RL. Evaluation of the Patient with a Wound. In: Hamm RL (ed). : McGraw Hill; 2015

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Lazaro JL, Izzo V, Meaume S, Davies AH Elevated levels of matrix metalloproteinases and chronic wound healing: an updated review of clinical evidence. J Wound Care. 2016; 25:(5)277-287

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Sinclair RD, Ryan TJ. Proteolytic enzymes in wound healing: the role of enzymatic debridement. Australas J Dermatol. 1994; 35:(1)35-41

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Focus: biofilm and infection

02 February 2019
Volume 3 · Issue 1

Autolysis: the natural physiologic process of disintegration of cells or tissues by endogenous enzymes; body's white blood cells and enzymes enter the wound site during the inflammatory phase of healing and liquefy the necrotic tissue; stimulated by a moist, vascular environment.1

Bioburden: degree of microbial contamination or microbial load; the number and effects of microorganisms contaminating a wound.

Biofilm: colonies of single bacterial or fungal species, or more commonly, polymicrobial organisms (bacterial, fungal, and possibly, viral) that group together and cover themselves with a slimy, glue-like protective coating (extracellular polymeric substance substance) to protect the colonies from outside invaders;2 biofilms can form on medical devices, in wounds, on sutures and many other surfaces.

Biosurgical debridement: the use of live sterile maggots to clean up and disinfect infected wounds; also known as maggot debridement therapy (MDT) or larval therapy.3

Cellular senescence: decreased or inability of a cell to proliferate/divide.4

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