Focus: biofilm and infection
Autolysis: the natural physiologic process of disintegration of cells or tissues by endogenous enzymes; body's white blood cells and enzymes enter the wound site during the inflammatory phase of healing and liquefy the necrotic tissue; stimulated by a moist, vascular environment.1
Bioburden: degree of microbial contamination or microbial load; the number and effects of microorganisms contaminating a wound.
Biofilm: colonies of single bacterial or fungal species, or more commonly, polymicrobial organisms (bacterial, fungal, and possibly, viral) that group together and cover themselves with a slimy, glue-like protective coating (extracellular polymeric substance substance) to protect the colonies from outside invaders;2 biofilms can form on medical devices, in wounds, on sutures and many other surfaces.
Biosurgical debridement: the use of live sterile maggots to clean up and disinfect infected wounds; also known as maggot debridement therapy (MDT) or larval therapy.3
Cellular senescence: decreased or inability of a cell to proliferate/divide.4
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