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Research

Cost-utility of a biofilm-disrupting gel versus standard of care in chronic wounds: a Markov microsimulation model based on a randomised controlled trial

Although there were a few VLUs in groups 1 and 2 and one PU in group 1, the differences in utility between unhealed and healed states are similar for these wounds compared to DFUs.17 (The difference...

Concurrent validity of biofilm detection by wound blotting on hard-to-heal wounds

This study showed concurrent validity with reference to native PAGE analysis for identifying and quantifying biofilm components through in vitro, in vivo and clinical investigations, as well as...

Development and assessment of a high-throughput biofilm and biomass testing platform

The 96-well plate biofilm method described here may provide an efficient and cost-effective high-throughput tool for studying biofilm formation, quantifying biofilm biomasses, testing antimicrobials...

Multicomponent compression system use in patients with chronic venous insufficiency: a real-life prospective study

Real-life data on the treatment of patients with CVI are still quite scarce in the literature, notably regarding the compression treatment of venous oedema, or patients' perception and acceptability...

A novel in vitro wound biofilm model used to evaluate low-frequency ultrasonic-assisted wound debridement

We have developed a novel in vitro wound biofilm model that mimics the non-surface attached spatial distribution of mature biofilms found in wounds. For this purpose, bacteria known to build biofilms...

Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial

This was a multicentre, open-label, randomised clinical trial conducted in 19 outpatient centres, geographically spread across the US. The primary objective of the study was to investigate the healing...

Preventing facial pressure ulcers in patients under non-invasive mechanical ventilation: a randomised control trial

The correct choice of the ventilatory interface is essential to obtain good outcomes with NIV. In general, the nasal mask is better tolerated, while the oro-nasal mask produces a faster reduction of...

Predictive validity of the braden scale for assessing risk of developing pressure ulcers and dependence-related lesions

A total of 295 patients were recruited. Of these, 81 (27.5%) developed DRL. The density of incidence was 41 DRL/1000 days at risk. The flow diagram for the sample is shown in Fig 1. Sociodemographic...

Use of wet-to-moist cleansing with different irrigation solutions to reduce bacterial bioburden in chronic wounds

All data analysed were collected as part of routine diagnosis and treatment, and patients were diagnosed and treated according to national guidelines and standards.8,9,10 All included patients gave...

Effect of a wound cleansing solution on wound bed preparation and inflammation in chronic wounds: a single-blind RCT

To compare the clinical efficacy of a PP solution versus NS solution, assessing inflammatory signs and wound size in patients with pressure ulcers (PUs) or vascular leg ulcers..

A comparative analysis of skin substitutes used in the management of diabetic foot ulcers

DFUs that do not heal with standard care alone can be successfully treated with skin substitutes. However, these skin substitutes can be expensive, and once their use is initiated, treatment may still...