Gottrup F. A specialized wound-healing center concept: importance of a multidisciplinary department structure and surgical treatment facilities in the treatment of chronic wounds. Am J Surg. 2004; 187:(5A)38S-43S

Fife CE, Eckert KA, Carter MJ. Publicly reported wound healing rates: the fantasy and the reality. Adv Wound Care (New Rochelle). 2018; 7:(3)77-94

Nussbaum SR, Carter MJ, Fife CE An economic evaluation of the impact, cost, and Medicare policy implications of chronic nonhealing wounds. Value Health. 2018; 21:(1)27-32

Niederauer MQ, Michalek JE, Liu Q Continuous diffusion of oxygen improves diabetic foot ulcer healing when compared with a placebo control: a randomised, double-blind, multicenter study. J Wound Care. 2018; 27:S30-S45

Frykberg RG, Franks PJ, Edmonds M A multinational, multicenter, randomized, double-blinded, placebo-controlled trial to evaluate the efficacy of cyclical topical wound oxygen therapy (TWO2) in the treatment of chronic diabetic foot ulcers: the TWO2 study. Diabetes Care. 2020; 43:(3)616-624

Serena TE, Bullock NM, Cole W Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial. J Wound Care. 2021; 30:S7-S14

Thanigaimani S, Singh T, Golledge J. Topical oxygen therapy for diabetes-related foot ulcers: a systematic review and meta-analysis,”. Diabet Med. 2021; 38:(8)

Eubank BH, Mohtadi NG, Lafave MR Using the modified Delphi method to establish clinical consensus for the diagnosis and treatment of patients with rotator cuff pathology. BMC Med Res. 2016; 16

Kim PJ, Attinger CE, Steinberg AS Negative-pressure wound therapy with instillation: international consensus guidelines. Plast Reconstr Surg. 132:(6)1569-1579

Serena T, Bates-Jensen B, Carter MJ Consensus principles for wound care research obtained using a Delphi process. Wound Repair Regen. 2012; 20:(3)284-293

Guidelines for the use of topical oxygen therapy in the treatment of hard-to-heal wounds based on a delphi consensus

02 September 2021
4 min read
Volume 5 · Issue 4

Agrowing body of evidence supports the use of topical oxygen therapy (TOT) in the treatment of diabetic foot ulcers (DFUs). Anecdotal evidence suggests that topical oxygen may be effective in the treatment of other wound types. In May 2021, leaders in the field of wound healing from across the US assembled in New Orleans. In one of the interactive sessions, several physicians reviewed and discussed the evidence for TOT, and attendees shared their experiences in treating patients with TOT. The conference highlighted the need for a consensus document for the use of topical oxygen in patients with hard-to-heal wounds. Subsequently, a Delphi method was employed to establish consensus guidelines for prescribing TOT. A multidisciplinary panel of 23 wound experts (15 wound specialists, six vascular surgeons, one plastic surgeon, one critical care provider and one PhD researcher) participated in two rounds of questionnaires. The Delphi survey questions focused on the indications for topical oxygen, when to prescribe the therapy, pretreatment work-up, visit frequency and length of therapy. A clinical workflow algorithm was also included as part of the Delphi. After two rounds, the Delphi participants were able to reach a consensus of >77% on when to prescribe topical oxygen, the wound types that may benefit from the therapy, pretreatment wound preparation, work-up and length of therapy. The goal of the guidelines is to standardise the use of topical oxygen and inform further research efforts.

Register now to continue reading

Thank you for visiting Wound Central and reading some of our peer-reviewed resources for wound care professionals. To read more, please register today. You’ll enjoy the following great benefits:

What's included

  • Access to clinical or professional articles

  • New content and clinical updates each month